If you are looking for a supplement that helps ease symptoms of PMDD/PMS, perimenopause, or estrogen dominance, you may want to try calcium D-glucarate. Your body might struggle to detox estrogen, which might be worse with high histamine, as high HIT creates even more estrogen.

It might calm you down, and improve your mood, sleep quality, and focus. I have been taking CDG from Source Naturals for a couple of years. I have had no negative symptoms at all, even on high doses.

Pros:

GMP certification, brand reputation, and manufacturing controls.

Cons:

-The pills are larger than usual; it helps to break them in half to make them easier to swallow.

-Has fillers – ensure you are okay with: sorbitol, stearic acid, modified cellulose gum, silica or magnesium stearate.

What are the other benefits of CDG?

• It is natural – a “substance produced naturally in small amounts by mammals, including humans. Glucaric acid is also found in many fruits and vegetables, with the highest concentrations to be found in oranges, apples, grapefruit, and cruciferous vegetables.”
• It helps balance hormones – “Other potential clinical applications of oral calcium-D-glucarate include regulation of estrogen metabolism and as a lipid-lowering agent.”
• It detoxes the liver – “Oral supplementation of calcium-D-glucarate has been shown to inhibit beta-glucuronidase, an enzyme produced by colonic microflora and involved in Phase II liver detoxification.”
• It lowers the risk of cancer – “Elevated beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers such as breast, prostate, and colon cancers.”
• Calcium helps to clear out oxalates.

REFERENCE:

https://drbeckycampbell.com/the-histamine-estrogen-connection/